Structural and functional properties of astrocytes on PCL based electrospun fibres

Increasing evidences are demonstrating that structural and functional properties of non-neuronal brain cells, called astrocytes, such as those cytoskeleton ion channels, critical for physiology. Also, changes in astrocytes structure function concur to might determine the outcome neuronal damage acute neurological conditions or chronic disease. Thus, design engineering biomaterials can drive is growing interest neuroregenerative medicine. Poly-?-caprolactone (PCL), FDA-approved polyester having excellent mechanical chemical be tailored obtain neural implants regenerative purposes. However, study on use PCL substrates purposes mainly aimed at investigating interaction material with neurons. Here, we report long-term viability, morphology, primary grown electrospun fibres (?GEL) blending Gelatin protein (+GEL). We found topography morphological features substrate drives adhesion survival, over long term, while they do not alter cell function. Specifically, aligned induced a dramatic actin-cytoskeletal rearrangement well focal point number distribution. Interestingly, observed elongated correlated alterations their electrophysiological properties. Our results indicated permissive tuned selectively alters components preserving The open view based target treatment dysfunction injuries chronical